Effects of chronic sugar consumption on lipid accumulation and autophagy in the skeletal muscle.

Daniela De StefanisRaffaella MastrocolaDebora NigroPaola CostelliManuela Aragno

Published in: European journal of nutrition (2015)

The present results suggest that intramyocellular lipids and the pro-inflammatory signaling could contribute to the onset of insulin resistance and lead to the induction of autophagy, which could be an adaptive response to lipotoxicity.

Keyphrases

insulin resistance
skeletal muscle
cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress
adipose tissue
high fat diet
metabolic syndrome
polycystic ovary syndrome
high fat diet induced
fatty acid
drug induced