Interleukin-11 drives human and mouse alcohol-related liver disease.
Maria EffenbergerAnissa A WidjajaFelix GrabherrBenedikt SchaeferChristoph GranderLisa MayrJulian SchwaerzlerBarbara EnrichPatrizia MoserJulia FinkAlisa PedriniNikolai JaschkeAlexander KirchmairAlexandra PfisterBela HausmannReto BaleDaniel PutzerHeinz ZollerSebastian SchaferPetra PjevacZlatko TrajanoskiGeorg OberhuberTimon AdolphStuart CookHerbert TilgPublished in: Gut (2022)
Pathogenic IL-11 signalling in hepatocytes plays a crucial role in the pathogenesis of ALD and could serve as an independent prognostic factor for transplant-free survival. Blocking IL-11 signalling might be a therapeutic option in human ALD, particularly AH.