The multiple roles of RAB GTPases in female and male meiosis.

Published in: Human reproduction update (2022)

Abnormal expression of RAB GTPases disrupts intracellular systems, which may induce diverse diseases. The roles of RAB proteins in female and male reproductive systems, thus, need to be considered. The mechanisms underlying the function of RAB GTPases and the binding specificity of their effectors during oogenesis, spermatogenesis and fertilization remain to be studied. This review should contribute to our understanding of the molecular mechanisms of oogenesis and spermatogenesis and potential genetic causes of infertility.

Keyphrases

poor prognosis
binding protein
genome wide
type diabetes
metabolic syndrome
gene expression
risk assessment
copy number
reactive oxygen species
human health
skeletal muscle
polycystic ovary syndrome
type iii
structural basis