Bortezomib treatment induces a higher mortality rate in lupus model mice with a higher disease activity.
Tomoko IkedaHiroshi FujiiMasato NoseYukiko KamogawaTsuyoshi ShiraiYuko ShirotaTomonori IshiiHideo HarigaePublished in: Arthritis research & therapy (2017)
In spite of its therapeutic effect, Bz treatment had more toxic effects associated with increased proinflammatory cytokine levels in mice with a higher disease activity. Understanding the mechanism of the toxicity and developing preventive strategies against it is important for the safe clinical application of Bz in human SLE.
Keyphrases
- disease activity
- systemic lupus erythematosus
- rheumatoid arthritis
- rheumatoid arthritis patients
- ankylosing spondylitis
- juvenile idiopathic arthritis
- endothelial cells
- oxidative stress
- risk factors
- type diabetes
- cardiovascular disease
- metabolic syndrome
- adipose tissue
- coronary artery disease
- newly diagnosed
- combination therapy
- wild type