Rare but Recurrent ROS1 Fusions Resulting From Chromosome 6q22 Microdeletions are Targetable Oncogenes in Glioma.
Monika A DavareJacob J HendersonAnupriya AgarwalJacob P WagnerSudarshan R IyerNameeta ShahRandy WoltjerRomel SomwarStephen W GilheeneyAna C deCarvalhoTom MikkelsonErwin G Van MeirMarc LadanyiBrian J DrukerPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)
Our findings highlight that CNS tumors should be specifically interrogated for these rare intrachromosomal 6q22 microdeletion events that generate actionable ROS1 fusions. ROS1 fusions in primary brain cancer may be amenable for clinical intervention with kinase inhibitors, and this holds the potential of novel treatment paradigms in these treatment-refractory cancer types, particularly in glioblastoma.