DNA Methylation and Immune Cell Markers Demonstrate Evidence of Accelerated Aging in Patients with Chronic Hepatitis B Virus or Hepatitis C Virus, with or without Human Immunodeficienct Virus Co-infection.

Yevgeniy GindinAnuj GaggarAnna S LokHarry L A JanssenCarlo FerrariG Mani SubramanianZhaoshi JiangHenry MasurBenjamin EmmanuelBhawna PooniaShyam Kottilil

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)

Our findings suggest that patients with chronic viral hepatitis have accelerated epigenetic aging, that immune markers define biological age, and have the potential to assess the effects of therapeutic intervention on age acceleration.

Keyphrases

hepatitis b virus
dna methylation
hepatitis c virus
gene expression
endothelial cells
liver failure
randomized controlled trial
genome wide
human immunodeficiency virus
sars cov
induced pluripotent stem cells
copy number
hiv infected
antiretroviral therapy