A new phenylspirodrimane derivative from the deep-sea-derived fungus Stachybotrys chartarum FS705.
Shuo WangSaini LiYuchan ChenYanlin WangZhaoming LiuWei-Min ZhangHong DengPublished in: Natural product research (2024)
A new phenylspirodrimane derivative named stachybotrysin A ( 1 ), together with four known analogues ( 2 - 5 ) were isolated and purified from the solid culture of the deep-sea-derived Stachybotrys chartarum FS705. Their structures were determined by comprehensive spectroscopic analysis and the absolute configuration was evaluated by theoretical ECD calculations. Compounds 1 - 5 were evaluated for their cytotoxic, antibacterial and α -glucosidase inhibitory activities. The results showed that compound 2 displayed mild cytotoxicity with IC 50 values in the range of 8.88 ∼ 22.73 µM against four human tumour cell lines, SF-268, MCF-7, HepG-2, and A549. Compound 1 showed strong α -glucosidase inhibitory activity with an IC 50 value of 20.68 µM. Compounds 4 and 5 exhibited weak antibacterial activity against Bacillus subtilis .