Steroid Ligands, the Forgotten Triggers of Nuclear Receptor Action; Implications for Acquired Resistance to Endocrine Therapy.
Rachel BleachStephen F MaddenJames HawleySara CharmsazCigdem SelliKatherine M SheehanLeonie S YoungAndrew H SimsPavel SoučekArnold D HillMarie McIlroyPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
This study highlights the importance of examining the therapeutic consequences of the steroid microenvironment and demonstrable receptor activation using indicative gene expression signatures.