Hypoxic mesenchymal stem cell-derived extracellular vesicles ameliorate renal fibrosis after ischemia-reperfusion injure by restoring CPT1A mediated fatty acid oxidation.

Zhumei GaoChuyue ZhangFei PengQianqian ChenYinghua ZhaoLiangmei ChenXu WangXiang-Mei Chen

Published in: Stem cell research & therapy (2022)

Hypo-EVs suppress the renal fibrosis by restoring CPT1A-mediated mitochondrial FAO, which effects may be achieved through regulation of mitochondrial homeostasis. Our findings provide further mechanism support for development cell-free therapy of renal fibrosis.

Keyphrases

cell free
fatty acid
oxidative stress
mesenchymal stem cells
bone marrow
circulating tumor
replacement therapy