Post-transplant сyclophosphamide after matched donor hematopoietic stem cell transplantation in children with acute leukemia.
Anastasya Svyatoslavovna BorovkovaOlesya Vladimirovna PainaElena Vladimirovna SemenovaTatiana Alexandrovna BykovaAnna Alekseevna OsipovaOlga Alexandrovna SlesarchukPolina Valerievna KozhokarLubov Alexandrovna TsvetkovaZhemal Zarifovna RakhmanovaAndrei Vadimovich KozlovAlexei Borisovich ChukhlovinIlya Viktorovich KazantsevMaria Arkadievna EstrinaOleg Valerievich GoloshchapovSergei Nikolaevich BondarenkoIvan Sergeevich MoiseevAlexander Dmitrievich KulaginLudmila Stepanovna ZubarovskayaPublished in: Clinical transplantation (2023)
In pediatric acute leukemia, PTCy-based GVHD prophylaxis for MUD allo-HSCT is a feasible and effective option that results in a low incidence of GVHD. Compared to the ATG-based approach, PTCy provides better control of GVHD in children. In pediatric allo-HSCT from MSD, PTCy demonstrates comparable effectiveness to conventional GVHD prophylaxis.