Zika virus-induced TNF-α signaling dysregulates expression of neurologic genes associated with psychiatric disorders.
Po-Lun KungTsui-Wen ChouMarissa LindmanNydia P ChangIrving EstevezBenjamin D BuckleyColm AtkinsBrian P DanielsPublished in: Journal of neuroinflammation (2022)
Our studies reveal that cell-intrinsic innate immune responses to ZIKV infection profoundly shape neuronal transcriptional profiles, highlighting the need to further explore associations between ZIKV infection and disordered host behavioral states.
Keyphrases
- zika virus
- immune response
- dengue virus
- single cell
- aedes aegypti
- poor prognosis
- rheumatoid arthritis
- gene expression
- high glucose
- transcription factor
- dendritic cells
- cell therapy
- diabetic rats
- genome wide
- stem cells
- drug induced
- case control
- dna methylation
- long non coding rna
- inflammatory response
- brain injury
- heat shock
- subarachnoid hemorrhage
- heat stress