Triptonide Modulates MAPK Signaling Pathways and Exerts Anticancer Effects via ER Stress-Mediated Apoptosis Induction in Human Osteosarcoma Cells.

Liyun ZhengShiji FangJunguo HuiVinothkumar RajamanickamMinjiang ChenQiaoyou WengXulu WuZhongwei ZhaoJian-Song Ji

Published in: Cancer management and research (2020)

Altogether, the outcome of the study for the first time revealed that TN exhibited its potential chemotherapeutic effects through ROS-mediated ER stress-induced apoptosis via p38 and ERK MAPK signaling pathways.

Keyphrases

induced apoptosis
signaling pathway
pi k akt
oxidative stress
endoplasmic reticulum stress
epithelial mesenchymal transition
cell cycle arrest
endothelial cells
cell death
induced pluripotent stem cells
pluripotent stem cells