Activation of the JAK/STAT3 and PI3K/AKT pathways are crucial for IL-6 trans-signaling-mediated pro-inflammatory response in human vascular endothelial cells.

Mulugeta Melkie ZegeyeMadelene LindkvistKnut FälkerAshok K KumawatGeena ParamelMagnus GrenegårdAllan SirsjöLiza U Ljungberg

Published in: Cell communication and signaling : CCS (2018)

Collectively, our study reports molecular differences in IL-6 classic- and trans-signaling in human vascular endothelial cells; and elucidates the pathways which mediate MCP-1 induction by IL-6 trans-signaling.

Keyphrases

endothelial cells
pi k akt
high glucose
signaling pathway
vascular endothelial growth factor
cell proliferation
induced pluripotent stem cells
pluripotent stem cells
cell cycle arrest
single molecule