Robust generation of human-chambered cardiac organoids from pluripotent stem cells for improved modelling of cardiovascular diseases.

Beatrice Xuan HoJeremy Kah Sheng PangYing ChenYuin-Han LohOmer AnHenry He YangVeerabrahma Pratap SeshachalamJudice L Y KohWoon-Khiong ChanShi Yan NgBoon-Seng Soh

Published in: Stem cell research & therapy (2022)

Our findings shed novel insights into the role of progenitors in CCO formation and pave the way for the robust generation of cardiac organoids, as a platform for future applications in disease modelling and drug screening in vitro.

Keyphrases

pluripotent stem cells
induced pluripotent stem cells
cardiovascular disease
left ventricular
endothelial cells
current status
high throughput
emergency department
coronary artery disease
atrial fibrillation
adverse drug