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Predicting gene expression changes upon epigenomic drug treatment.

Piyush AgrawalVishaka GopalanSridhar Hannenhalli
Published in: bioRxiv : the preprint server for biology (2023)
Here we present a first assessment of the predictability of genome-wide transcriptomic changes upon treatment with HDACi. Lack of appropriate omics data from clinical trials of epigenetic drugs currently hampers the assessment of applicability of our approach in clinical setting.
Keyphrases
  • gene expression
  • dna methylation
  • genome wide
  • clinical trial
  • single cell
  • randomized controlled trial
  • machine learning
  • combination therapy
  • rna seq
  • copy number
  • study protocol
  • double blind