A two-decade journey in identifying high mobility group box 1 (HMGB1) and procathepsin L (Pcts-L) as potential therapeutic targets for sepsis .

Jianhua LiCassie Shu ZhuLi HeXiaoling QiangWeiqiang ChenHaichao Wang

Published in: Expert opinion on therapeutic targets (2023)

It will be important to evaluate the efficacy of HMGB1- or pCTS-L-targeting agents for the clinical management of human sepsis and other infectious diseases in future studies.

Keyphrases

infectious diseases
septic shock
acute kidney injury
intensive care unit
endothelial cells
current status
induced pluripotent stem cells
pluripotent stem cells
binding protein
risk assessment
climate change