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Recent Advances in Systemic Therapies for Advanced Hepatocellular Carcinoma.

Gabriella AitchesonAnjana PillaiBassam DahmanBinu V John
Published in: Current hepatology reports (2021)
After almost a 10-year dormancy, the list of potential systemic treatment options for aHCC is growing rapidly. Given the promising data from the IMbrave150 trial, the combination of atezolizumab and bevacizumab is now the new first-line therapy. We discuss the change in landscape, the new second- and third-line systemic treatments in aHCC, and the ongoing clinical trials for newer agents including combination therapies.
Keyphrases
  • clinical trial
  • phase ii
  • study protocol
  • phase iii
  • big data
  • randomized controlled trial
  • single cell
  • stem cells
  • machine learning
  • mesenchymal stem cells
  • deep learning
  • artificial intelligence
  • double blind