PTEN promoter methylation predicts 10-year prognosis in hormone receptor-positive early breast cancer patients who received adjuvant tamoxifen endocrine therapy.

Yu FanGuiqin XieZhu WangYu WangYanping WangHong ZhengXiao-Rong Zhong

Published in: Breast cancer research and treatment (2022)

Low PTEN expression and high methylation of its promoter (sequence - 819 to - 787 bp) in tissue predict poor DFS and OS in hormone receptor-positive early BC patients who received adjuvant TAM.

Keyphrases

dna methylation
early breast cancer
early stage
genome wide
cell proliferation
pi k akt
gene expression
transcription factor
poor prognosis
signaling pathway
estrogen receptor
positive breast cancer
stem cells
binding protein
amino acid
bone marrow