Punicalagin Attenuates LPS-Induced Inflammation and ROS Production in Microglia by Inhibiting the MAPK/NF-κB Signaling Pathway and NLRP3 Inflammasome Activation.
Jung LoChing-Chih LiuYueh-Shan LiLiang-Yu ChenPo-Len LiuPei-Chang WuTzu-Chieh LinChi-Shuo ChenChien-Chih ChiuYu-Hung LaiYo-Chen ChangHsin-En WuYuan-Ru ChenYu-Kai HuangShu-Pin HuangShu-Chi WangChia-Yang LiPublished in: Journal of inflammation research (2022)
Our results demonstrated that punicalagin attenuated LPS-induced inflammation through suppressing the expression of iNOS and COX-2, inhibited the activation of MAPK/NF-κB signaling pathway and NLRP3 inflammasome, and reduced the production of ROS in microglia, suggesting that punicalagin might have the potential in treating neurodegenerative diseases.
Keyphrases
- lps induced
- signaling pathway
- nlrp inflammasome
- inflammatory response
- pi k akt
- oxidative stress
- induced apoptosis
- epithelial mesenchymal transition
- dna damage
- cell death
- toll like receptor
- reactive oxygen species
- poor prognosis
- neuropathic pain
- binding protein
- risk assessment
- immune response
- long non coding rna
- human health