Transplantation Outcomes with Donor Hearts after Circulatory Death.
Jacob N SchroderChetan B PatelAdam D DeVoreBenjamin S BrynerSarah CasalinovaAshish ShahJason W SmithAmy G FiedlerMani DaneshmandScott SilvestryArnar GeirssonVictor PretoriusDavid L JoyceJohn Y UmFardad EsmailianKoji TakedaKarol MudyYasuhiro ShudoChristopher T SalernoSi M PhamDaniel J GoldsteinJonathan PhilpottJohn DunningLucian LozonschiGregory S CouperHari Reddy MallidiMichael M GivertzDuc Thinh PhamAndrew W ShafferMasashi KaiMohammed A QuaderTarek AbsiTamer S AttiaBassam ShukrallahBen C SunMaryjane FarrMandeep R MehraJoren C MadsenCarmelo A MilanoDavid A D'AlessandroPublished in: The New England journal of medicine (2023)
In this trial, risk-adjusted survival at 6 months after transplantation with a donor heart that had been reanimated and assessed with the use of extracorporeal nonischemic perfusion after circulatory death was not inferior to that after standard-care transplantation with a donor heart that had been preserved with the use of cold storage after brain death. (Funded by TransMedics; ClinicalTrials.gov number, NCT03831048.).
Keyphrases
- heart failure
- cell therapy
- healthcare
- atrial fibrillation
- clinical trial
- extracorporeal membrane oxygenation
- study protocol
- randomized controlled trial
- stem cells
- type diabetes
- multiple sclerosis
- phase iii
- affordable care act
- quality improvement
- metabolic syndrome
- magnetic resonance imaging
- cerebral ischemia
- subarachnoid hemorrhage
- insulin resistance
- weight loss
- breast cancer risk