Increased MLKL mRNA level in the PBMCs is correlated with autoantibody production, renal involvement, and SLE disease activity.
Mingjiao ZhangHongyu JieYong WuXinai HanXing LiYi HeXingliang ShiYuwei LuoYing SunJinlong YangJing YangShulv QuanXiaobin LaoLiping TanErwei SunPublished in: Arthritis research & therapy (2020)
These results suggest that increased MLKL mRNA level in the PBMCs of SLE patients is correlated with renal involvement and disease activity, identifying a subgroup of patients with SLE or LN who may benefit from early diagnosis and therapies targeting MLKL.