Preliminary findings of German-sourced ONC201 treatment in H3K27 altered pediatric pontine diffuse midline gliomas.

Bahattin Tanrıkulu Ahmet Harun Yaşar Cengiz Canpolat Funda Vesile Çorapcıoğlu Evrim Tezcanli Ufuk Abacioglu Ayça Erşen Danyeli M Memet Özek

Published in: Journal of neuro-oncology (2023)

In conclusion, this study suggests that GsONC201 may improve OS in pediatric H3K27-altered pDMG patients without significant side effects. However, caution is warranted due to retrospective design and biases, highlighting the need for further randomized clinical studies to validate these findings.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
open label
double blind
peritoneal dialysis
cross sectional
low grade
phase iii
young adults
combination therapy
placebo controlled