Pancreatic fatty replacement as risk marker for altered glucose metabolism and cardiac iron and complications in thalassemia major.
Antonella MeloniMario NobilePetra KeilbergVincenzo PositanoMaria Filomena SantarelliLaura PistoiaAnna SpasianoTommaso CasiniMaria Caterina PuttiLiana CucciaPier Paolo BittiGiuseppe MessinaGiuseppe PeritoreStefania RenneEmanuele GrassedonioEmilio QuaiaFilippo CademartiriAlessia PepePublished in: European radiology (2023)
• In thalassemia major, pancreatic fatty replacement by MRI is a frequent clinical entity, predicted by a pancreas T2* < 20.81 ms and associated with a higher risk of alterations in glucose metabolism. • In thalassemia major, pancreatic fatty replacement is a strong risk marker for cardiac iron, replacement fibrosis, and complications, highlighting a deep connection between pancreatic and cardiac impairment.