Mild cognitive impairment and structural brain abnormalities in a sexagenarian with a history of childhood traumatic brain injury.
John Darrell Van HornAndrei IrimiaCarinna M TorgersonAvnish BhattraiZachary JacokesPaul M VespaPublished in: Journal of neuroscience research (2017)
In this report, we present a case study involving an older, female patient with a history of pediatric traumatic brain injury (TBI). Magnetic resonance imaging and diffusion tensor imaging volumes were acquired from the volunteer in question, her brain volumetrics and morphometrics were extracted, and these were then systematically compared against corresponding metrics obtained from a large sample of older healthy control (HC) subjects as well as from subjects in various stages of mild cognitive impairment (MCI) and Alzheimer disease (AD). Our analyses find the patient's brain morphometry and connectivity most similar to those of patients classified as having early-onset MCI, in contrast to HC, late MCI, and AD samples. Our examination will be of particular interest to those interested in assessing the clinical course in older patients having suffered TBI earlier in life, in contradistinction to those who experience incidents of head injury during aging.
Keyphrases
- mild cognitive impairment
- traumatic brain injury
- resting state
- early onset
- cognitive decline
- white matter
- functional connectivity
- magnetic resonance imaging
- end stage renal disease
- late onset
- severe traumatic brain injury
- case report
- chronic kidney disease
- newly diagnosed
- ejection fraction
- middle aged
- cerebral ischemia
- physical activity
- community dwelling
- magnetic resonance
- prognostic factors
- contrast enhanced
- peritoneal dialysis
- multiple sclerosis
- childhood cancer
- brain injury
- blood brain barrier
- mild traumatic brain injury