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The Role of Platelets in Infective Endocarditis.

Mustapha Abdeljalil BraïNadji HannachiNabila El GueddariJean-Pierre BaudoinAbderrhamane DahmaniHubert LepidiGilbert HabibLaurence Camoin-Jau
Published in: International journal of molecular sciences (2023)
Over the last decade, the incidence of infective endocarditis (IE) has increased, with a change in the frequency of causative bacteria. Early evidence has substantially demonstrated the crucial role of bacterial interaction with human platelets, with no clear mechanistic characterization in the pathogenesis of IE. The pathogenesis of endocarditis is so complex and atypical that it is still unclear how and why certain bacterial species will induce the formation of vegetation. In this review, we will analyze the key role of platelets in the physiopathology of endocarditis and in the formation of vegetation, depending on the bacterial species. We provide a comprehensive outline of the involvement of platelets in the host immune response, investigate the latest developments in platelet therapy, and discuss prospective research avenues for solving the mechanistic enigma of bacteria-platelet interaction for preventive and curative medicine.
Keyphrases
  • immune response
  • climate change
  • endothelial cells
  • red blood cell
  • stem cells
  • induced pluripotent stem cells
  • rectal cancer
  • mesenchymal stem cells
  • pluripotent stem cells
  • bone marrow
  • dendritic cells