4-Hydroxynonenal impairs miRNA maturation in heart failure via Dicer post-translational modification.

Ligia A KiyunaDarlan S CandidoLuiz R G BecharaItamar C G JesusLisley S RamalhoBarbara KrumRuda P AlbuquerqueJuliane C CamposLuiz H M BoziVanessa O ZambelliAriane N AlvesNicolás CampoloMauricio MastrogiovanniSilvina BartesaghiAlejandro LeyvaRosario DuránRafael RadiGuilherme M ArantesEdécio Cunha-NetoMarcelo A MoriChe-Hong ChenWenjin YangDaria-Mochly RosenIan J MacRaeLudmila R P FerreiraJulio Cesar Batista Ferreira

Published in: European heart journal (2023)

4-HNE inhibition of Dicer directly impairs miRNA biogenesis in heart failure. Strikingly, decreasing cardiac 4-HNE levels through pharmacological ALDH2 activation is sufficient to re-establish Dicer activity and miRNA biogenesis; thereby representing potential treatment for patients with heart failure.

Keyphrases

heart failure
left ventricular
cardiac resynchronization therapy
atrial fibrillation
acute heart failure
combination therapy
climate change