The Unique Pharmacometrics of Small Molecule Therapeutic Drug Tracer Imaging for Clinical Oncology.
Mark P S DunphyNagavarakishore PillarsettyPublished in: Cancers (2020)
Translational development of radiolabeled analogues or isotopologues of small molecule therapeutic drugs as clinical imaging biomarkers for optimizing patient outcomes in targeted cancer therapy aims to address an urgent and recurring clinical need in therapeutic cancer drug development: drug- and target-specific biomarker assays that can optimize patient selection, dosing strategy, and response assessment. Imaging the in vivo tumor pharmacokinetics and biomolecular pharmacodynamics of small molecule cancer drugs offers patient- and tumor-specific data which are not available from other pharmacometric modalities. This review article examines clinical research with a growing pharmacopoeia of investigational small molecule cancer drug tracers.
Keyphrases
- small molecule
- papillary thyroid
- cancer therapy
- protein protein
- high resolution
- squamous cell
- case report
- squamous cell carcinoma
- drug delivery
- drug induced
- palliative care
- randomized controlled trial
- electronic health record
- adverse drug
- emergency department
- childhood cancer
- big data
- study protocol
- single cell
- open label
- clinical evaluation