Alpha-synuclein mRNA isoform formation and translation affected by polymorphism in the human SNCA 3'UTR.

Elizabeth S BarrieSung-Ha LeeJohn T FraterMaria KatakiDouglas W ScharreWolfgang Sadee

Published in: Molecular genetics & genomic medicine (2018)

Here, we identify two cis-acting regulatory variants affecting SNCA mRNA expression, measured by allelic ratios in the 3'UTR. The rs17016074 minor A allele is associated with higher expression of luciferase protein activity. Resolving the genetic influence of SNCA polymorphisms requires study of the interactions between multiple regulatory variants with distinct frequencies among populations.

Keyphrases

copy number
binding protein
transcription factor
endothelial cells
poor prognosis
genome wide
protein protein
small molecule
genetic diversity