Sleep disturbances and upregulation of brain arousal during daytime in depressed versus non-depressed elderly subjects.

Christine UlkeChristian SanderPhilippe Jawinski Nicole MaucheJue HuangJanek SpadaDirk WittekindRoland MerglTobias LuckSteffi Riedel-HellerTilman HenschUlrich Hegerl

Published in: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry (2016)

The data confirm the hypothesis that in persons with depressive syndromes sleep disturbances are related to upregulation of brain arousal the next day. This finding is in line with the concept that dysregulation of brain arousal is a central pathophysiological aspect in depression.

Keyphrases

sleep quality
resting state
white matter
functional connectivity
poor prognosis
physical activity
cell proliferation
signaling pathway
obstructive sleep apnea
bipolar disorder
multiple sclerosis
big data
middle aged
machine learning
long non coding rna
drug induced