2D Material-Based Nanofibrous Membrane for Photothermal Cancer Therapy.
Jundong ShaoHanhan XieHuaiyu WangWenhua ZhouQian LuoXue-Feng YuPaul K ChuPublished in: ACS applied materials & interfaces (2017)
One of the clinical challenges facing photothermal cancer therapy is health risks imposed by the photothermal nanoagents in vivo. Herein, a photothermal therapy (PTT) platform composed of a 2D material-based nanofibrous membrane as the agent to deliver thermal energy to tumors under near-infrared (NIR) light irradiation is described. The photothermal membrane, which is fabricated by an electrospinning poly(l-lactic acid) (PLLA) nanofibrous membrane loaded with bismuth selenide (Bi2Se3) nanoplates, exhibits very high photothermal conversion efficiency and long-term stability. Cell experiments and hematological analyses demonstrate that the Bi2Se3/PLLA membranes have excellent biocompatibility and low toxicity. PTT experiments performed in vivo with the Bi2Se3/PLLA membrane covering the tumor and NIR irradiation produce local hyperthermia to ablate the tumor with high efficiency. Different from the traditional systematical and local injection techniques, this membrane-based PTT platform is promising in photothermal cancer therapy, especially suitable for the treatment of multiple solid tumors or skin cancers, and long-term prevention of cancer recurrence after surgery or PTT, while eliminating the health hazards of nanoagents.
Keyphrases
- cancer therapy
- drug delivery
- photodynamic therapy
- drug release
- high efficiency
- healthcare
- public health
- tissue engineering
- lactic acid
- mental health
- stem cells
- risk assessment
- mesenchymal stem cells
- social media
- papillary thyroid
- cell therapy
- climate change
- bone marrow
- squamous cell carcinoma
- soft tissue
- free survival
- wound healing
- single cell
- human health
- health promotion