Hyperglycaemia-induced human hepatocellular carcinoma (HepG2) cell proliferation through ROS-mediated P38 activation is effectively inhibited by a xanthophyll carotenoid, lutein.
Tehreem MaradagiRavi KumarGanesan PonesakkiPublished in: Diabetic medicine : a journal of the British Diabetic Association (2021)
Our findings portray that sufficient intake of lutein may offer a negative impact on diabetes-associated tumour growth.
Keyphrases
- cell proliferation
- endothelial cells
- high glucose
- type diabetes
- cardiovascular disease
- diabetic rats
- cell death
- induced pluripotent stem cells
- dna damage
- cell cycle
- pluripotent stem cells
- glycemic control
- reactive oxygen species
- oxidative stress
- skeletal muscle
- pi k akt
- insulin resistance
- signaling pathway
- adipose tissue