<SPAN style="font-size: 11.0pt; font-family: 'Arial',sans-serif;">Chimeric Antigen Receptor T Cell with an Inducible Caspase 9 Suicide Gene Eradicates Uveal Melanoma Liver Metastases via B7-H3 Targeting</SPAN>.
Marco VentinGiulia CattaneoShahrzad AryaJingyu JiaMaria Chiara GelmiYi SunLuke MaggsBruce R KsanderRobert M VerdijkGenevieve Marie BolandRussell William JenkinsRizwan HaqMartine J JagerXinhui WangSandra W RyeomCristina R FerronePublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
These studies support a phase I clinical trial with iCas9.B7-H3 CAR T cells to treat patients with metastatic UM.
Keyphrases
- liver metastases
- clinical trial
- cell death
- copy number
- cancer therapy
- genome wide
- phase ii
- case control
- study protocol
- induced apoptosis
- double blind
- open label
- genome wide identification
- randomized controlled trial
- phase iii
- gene expression
- dna methylation
- drug delivery
- endoplasmic reticulum stress
- transcription factor
- basal cell carcinoma