Deciphering the Pathways to PARP Sensitivity in Pancreatic Cancer.

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

A recent article analyzed paired cell-free (cf)DNA among patients with platinum-sensitive BRCA or PALB2-mutated pancreatic cancer who received maintenance olaparib. Reversion mutations were linked with worse outcomes. These types of paired correlative studies are needed to improve our understanding of drug resistance and guide future clinical trials.

Keyphrases

cell free
circulating tumor
clinical trial
cystic fibrosis
dna damage
dna repair
current status
case control
randomized controlled trial
type diabetes
weight loss
breast cancer risk
nucleic acid