Comparative Analysis of Human Nucleoside Kinase-Based Reporter Systems for PET Imaging.
Jason T LeeHanwen ZhangMaxim A MorozYury LikarLarissa ShenkerNikita SumzinJose LoboJuan ZuritaJeffrey CollinsR Michael van DamVladimir PonomarevPublished in: Molecular imaging and biology (2017)
We demonstrate that human nucleoside kinase reporter systems vary significantly in their sensitivity and selectivity for in vivo imaging. The sufficiently high signal-to-background ratios and enhanced suicide gene potential support clinical translation.