Rationale, design, and baseline participant characteristics in the MRI and cognitive substudy of the cardiovascular outcomes for people using anticoagulation strategies trial.
Mukul SharmaRobert G HartEric E SmithJackie BoschFei YuanAmparo CasanovaJohn W EikelboomStuart J ConnollyGloria WongRafael DiazPatricio Lopez-JaramilloGeorg ErtlStefan StörkGilles R DagenaisEva M LonnLars RydenAndrew M TonkinJohn D VarigosDeepak L BhattKelley Rh BranchJeffrey L ProbstfieldJae-Hyung KimJong-Won HaMartin O'DonnellDragos VinereanuKeith Aa FoxYan LiangLisheng LiuJun ZhuNana PogosovaAldo Pietro MaggioniAlvaro AvezumLeopoldo S PiegasKatalin KeltaiMatyas KeltaiNancy Cook BrunsScott BerkowitzSalim YusufPublished in: International journal of stroke : official journal of the International Stroke Society (2018)
The COMPASS MRI substudy will examine the effect of the antithrombotic interventions on MRI-determined covert brain infarcts and cognition. Demonstration of a therapeutic effect of the antithrombotic regimens on brain infarcts would have implications for prevention of cognitive decline and provide insight into the pathogenesis of vascular cognitive decline.
Keyphrases
- cognitive decline
- mild cognitive impairment
- contrast enhanced
- atrial fibrillation
- magnetic resonance imaging
- white matter
- diffusion weighted imaging
- clinical trial
- resting state
- venous thromboembolism
- computed tomography
- magnetic resonance
- cerebral ischemia
- study protocol
- randomized controlled trial
- phase iii
- multiple sclerosis
- brain injury
- blood brain barrier
- phase ii