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Rationale, design, and baseline participant characteristics in the MRI and cognitive substudy of the cardiovascular outcomes for people using anticoagulation strategies trial.

Mukul SharmaRobert G HartEric E SmithJackie BoschFei YuanAmparo CasanovaJohn W EikelboomStuart J ConnollyGloria WongRafael DiazPatricio Lopez-JaramilloGeorg ErtlStefan StörkGilles R DagenaisEva M LonnLars RydenAndrew M TonkinJohn D VarigosDeepak L BhattKelley Rh BranchJeffrey L ProbstfieldJae-Hyung KimJong-Won HaMartin O'DonnellDragos VinereanuKeith Aa FoxYan LiangLisheng LiuJun ZhuNana PogosovaAldo Pietro MaggioniAlvaro AvezumLeopoldo S PiegasKatalin KeltaiMatyas KeltaiNancy Cook BrunsScott BerkowitzSalim Yusuf
Published in: International journal of stroke : official journal of the International Stroke Society (2018)
The COMPASS MRI substudy will examine the effect of the antithrombotic interventions on MRI-determined covert brain infarcts and cognition. Demonstration of a therapeutic effect of the antithrombotic regimens on brain infarcts would have implications for prevention of cognitive decline and provide insight into the pathogenesis of vascular cognitive decline.
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