Define of Optimal Addition Period of Osteogenic Peptide to Accelerate the Osteogenic Differentiation of Human Pluripotent Stem Cells.

Yameng SongHongjiao LiZixuan WangJiamin ShiJing LiLu WangLingzi LiaoShengqin MaYun ZhangBin LiuYaling YangPing Zhou

Published in: Tissue engineering and regenerative medicine (2023)

The differentiation efficiency of cells could be improved by determining the optimal treatment period. Our study has great value in maximizing the differentiation of hPSCs by adding osteogenesis peptides based on the revealed mechanisms and promoting the application of hPSCs in bone tissue regeneration.

Keyphrases

pluripotent stem cells
induced apoptosis
stem cells
endothelial cells
mesenchymal stem cells
cell cycle arrest
bone mineral density
single cell
endoplasmic reticulum stress
postmenopausal women
cell proliferation
oxidative stress
combination therapy