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Prioritization of risk genes in multiple sclerosis by a refined Bayesian framework followed by tissue-specificity and cell type feature assessment.

Andi LiuAstrid M ManuelYulin DaiZhong-Ming Zhao
Published in: BMC genomics (2022)
In summary, we predicted and validated a high-confidence MS risk gene set from diverse genomic, epigenomic, eQTL, single-cell, and drug data. The MS-PRGenes could further serve as a benchmark of MS GWAS risk genes for future validation or genetic studies.
Keyphrases
  • multiple sclerosis
  • genome wide
  • mass spectrometry
  • ms ms
  • single cell
  • copy number
  • machine learning
  • dna methylation
  • big data
  • electronic health record
  • data analysis