Epigenetic silencing of IGFBPL1 promotes esophageal cancer growth by activating PI3K-AKT signaling.

Yingge LiuMeiying ZhangTao HeWeili YangLidong WangLirong ZhangMingzhou Guo

Published in: Clinical epigenetics (2020)

IGFBPL1 suppresses esophageal cancer cell growth by inhibiting PI3K-AKT signaling in vitro and in vivo. IGFBPL1 is a novel tumor suppressor in human esophageal cancer.

Keyphrases

pi k akt
signaling pathway
cell cycle arrest
endothelial cells
cell proliferation
dna methylation
gene expression
induced pluripotent stem cells
pluripotent stem cells