Identification of programmed cell death 1 and its ligand in the testicular tissue of mice.
Li-Ling WangZhi-Hui LiYong-Gang DuanShui-Qiao YuanGil MorAi-Hua LiaoPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2019)
PD-1 and PD-L1 were present in the testicular tissue of adult mice. The expression and localization of PD-1 fluctuated with age, and PD-1 was mainly localized to advanced germ cells, suggesting that it may play a role in spermiogenesis. PD-L1 was constitutively expressed in the nucleus of Sertoli cells, which could secrete sPD-L1 into the testicular interstitial space and thus may be involved in testicular immune privilege.