Antitumor Effect of Pseudolaric Acid B Involving Regulation of Notch1/Akt Signaling Response in Human Hepatoma Cell In Vitro.
Haijun GaoYan ZhangXiaojin MoLele HuoYanping LuoTing ZhangXing-Ming MaWei HuTao JingPublished in: Evidence-based complementary and alternative medicine : eCAM (2022)
PAB can suppress proliferation and invasion of HCC cells through downregulating the expression of Notch1/Akt signaling protein and mRNA, and may be a potential novel antitumor drug candidate for the clinical treatment of HCC in the future.
Keyphrases
- cell proliferation
- signaling pathway
- induced apoptosis
- binding protein
- endothelial cells
- poor prognosis
- cell cycle arrest
- single cell
- cell therapy
- induced pluripotent stem cells
- emergency department
- pi k akt
- cell death
- adverse drug
- human health
- mesenchymal stem cells
- bone marrow
- combination therapy
- long non coding rna