L-carnitine infusion does not alleviate lipid-induced insulin resistance and metabolic inflexibility.

Yvonne M H BrulsYvo J M Op den KampEsther PhielixLucas LindeboomBas HavekesGert SchaartEsther Moonen-KornipsJoachim E WildbergerMatthijs K C HesselinkPatrick SchrauwenVera B Schrauwen-Hinderling

Published in: PloS one (2020)

Acute L-carnitine infusion could not alleviated lipid-induced insulin resistance and metabolic inflexibility and did not alter skeletal muscle carnitine availability. Possibly, lipid-induced insulin resistance may also have affected carnitine uptake and may have blunted the insulin-induced carnitine storage in muscle. Future studies are needed to investigate this.

Keyphrases

insulin resistance
skeletal muscle
high glucose
type diabetes
diabetic rats
drug induced
adipose tissue
metabolic syndrome
high fat diet
low dose
polycystic ovary syndrome
fatty acid
current status
acute respiratory distress syndrome
aortic dissection