Researchers' experiences of the design and conduct challenges associated with parallel-group cluster-randomised trials and views on a novel open-cohort design.

Claire A Surr Laura MarsdenAlys GriffithsSharon CoxJane FosseyAdam MartinAndrew Toby Prevost Catherine Walshe Rebecca Walwyn

Published in: PloS one (2024)

Open-cohort CRT designs hold promise for addressing the challenges associated with standard CRT designs. Research is needed to provide clarity around definition and guidance on application.

Keyphrases

minimally invasive
cardiac resynchronization therapy
clinical trial
open label
mental health
heart failure
double blind
randomized controlled trial
left ventricular