Decoding ceRNA regulatory network in the pulmonary artery of hypoxia-induced pulmonary hypertension (HPH) rat model.

Jun WangYanqin NiuLingjie LuoZefeng LuQinghua ChenShasha ZhangQianwen GuoLi LiDeming Gou

Published in: Cell & bioscience (2022)

A ceRNA regulatory network in the pulmonary arteries of HPH rats was constructed, 10 hub miRNAs and their corresponding interacting lncRNAs, circRNAs, and mRNAs were identified. The expression patterns of selected DERNAs were further validated to be consistent with the sequencing result. POSTN, LTBP2, SPP1, and LSAMP were suggested to be potential diagnostic biomarkers and therapeutic targets for PAH.

Keyphrases

pulmonary hypertension
pulmonary artery
network analysis
long non coding rna
pulmonary arterial hypertension
poor prognosis
transcription factor
coronary artery
wastewater treatment
binding protein
blood flow