A phase I pharmacokinetic and safety study of Paclitaxel Injection Concentrate for Nano-dispersion (PICN) alone and in combination with carboplatin in patients with advanced solid malignancies and biliary tract cancers.
Wen Wee MaMojun ZhuElaine T LamJennifer R DiamondGrace K DyGeorge A FisherLaura Williams GoffSteven AlbertsLynne A BuiAkhil SanghalMudgal KothekarAjay KhopadeGeetanjali ChimoteRobert FaulknerS Gail EckhardtAlex A AdjeiAntonio JimenoPublished in: Cancer chemotherapy and pharmacology (2021)
This study demonstrated the safety and stable pharmacokinetics of PICN as a monotherapy and in combination with carboplatin. Single-agent PICN showed promising antitumor activity in advanced BTCs, warranting further studies to investigate its role in gastrointestinal cancers.