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Genome-wide association study reveals BET1L associated with survival time in the 137,693 Japanese individuals.

Masato AkiyamaSaori SakaueAtsushi TakahashiKazuyoshi IshigakiMakoto HirataKoichi MatsudaYukihide MomozawaYukinori OkadaToshiharu Ninomiyanull nullChikashi C TeraoYoshinori MurakamiMichiaki KuboYoichiro Kamatani
Published in: Communications biology (2023)
Human lifespan is reported to be heritable. Although previous genome-wide association studies (GWASs) have identified several loci, a limited number of studies have assessed the genetic associations with the real survival information on the participants. We conducted a GWAS to identify loci associated with survival time in the Japanese individuals participated in the BioBank Japan Project by carrying out sex-stratified GWASs involving 78,029 males and 59,664 females. Of them, 31,324 (22.7%) died during the mean follow-up period of 7.44 years. We found a novel locus associated with survival (BET1L; P = 5.89 × 10 -9 ). By integrating with eQTL data, we detected a significant overlap with eQTL of BET1L in skeletal muscle. A gene-set enrichment analysis showed that genes related to the BCAR1 protein-protein interaction subnetwork influence survival time (P = 1.54 × 10 -7 ). These findings offer the candidate genes and biological mechanisms associated with human lifespan.
Keyphrases
  • genome wide association study
  • genome wide association
  • skeletal muscle
  • endothelial cells
  • free survival
  • protein protein
  • healthcare
  • machine learning
  • copy number
  • dna methylation
  • big data
  • health information