Shielding Effect of Ryanodine Receptor Modulator in Rat Model of Autism.
Hariom KumarG T KulkarniVishal DiwanBhupesh SharmaPublished in: Basic and clinical neuroscience (2023)
Autism is a complex heterogeneous neurodevelopmental disorder mainly diagnosed with social behavior dysfunction, communication problems, and repetitive behavior. Due to high comorbidity and multiple unknown factors involvement, its exact etiology remains unclear, and so no successful treatment is available. Among the environmentally produced models of autism in rats, the most common is created by propionic acid (PPA). With short-chain type fatty acid, PPA is one of the mediators for the cycle of cell metabolism. This study attempted to study the effect of a ryano-dine receptor antagonist (Ruthenium red) on PPA-induced Anxiety, social behavior dysfunction, and repeated behaviors in rats with autism. The results showed the modulatory effects of Ruthenium red PPA-induced conditions including social and repetitive behavior, oxidative stress, neuroinflammation, and neuroprotein changes in rats with autism.
Keyphrases
- autism spectrum disorder
- intellectual disability
- oxidative stress
- mental health
- diabetic rats
- healthcare
- fatty acid
- high glucose
- high frequency
- traumatic brain injury
- stem cells
- density functional theory
- lipopolysaccharide induced
- physical activity
- endothelial cells
- ischemia reperfusion injury
- binding protein
- molecular dynamics
- induced apoptosis
- heat shock
- endoplasmic reticulum stress
- bone marrow
- cerebral ischemia