Breaking Barriers: A Future Perspective on Glioblastoma Therapy with mRNA-Based Immunotherapies and Oncolytic Viruses.
Alexandro GuterresPaulo Niemeyer Soares FilhoVivaldo Moura NetoPublished in: Vaccines (2024)
The use of mRNA-based immunotherapies that leverage the genomes of oncolytic viruses holds significant promise in addressing glioblastoma (GBM), an exceptionally aggressive neurological tumor. We explore the significance of mRNA-based platforms in the area of immunotherapy, introducing an innovative approach to mitigate the risks associated with the use of live viruses in cancer treatment. The ability to customize oncolytic virus genome sequences enables researchers to precisely target specific cancer cells, either through viral genome segments containing structural proteins or through a combination of regions with oncolytic potential. This strategy may enhance treatment effectiveness while minimizing unintended impacts on non-cancerous cells. A notable case highlighted here pertains to advanced findings regarding the application of the Zika virus (ZIKV) in GBM treatment. ZIKV, a member of the family Flaviviridae, shows oncolytic properties against GBM, opening novel therapeutic avenues. We explore intensive investigations of glioblastoma stem cells, recognized as key drivers in GBM initiation, progression, and resistance to therapy. However, a comprehensive elucidation of ZIKV's underlying mechanisms is imperative to pave the way for ZIKV-based clinical trials targeting GBM patients. This investigation into harnessing the potential of oncolytic-virus genomes for mRNA-based immunotherapies underscores its noteworthy implications, potentially paving the way for a paradigm shift in cancer treatment strategies.
Keyphrases
- zika virus
- dengue virus
- stem cells
- aedes aegypti
- clinical trial
- end stage renal disease
- binding protein
- randomized controlled trial
- systematic review
- chronic kidney disease
- sars cov
- induced apoptosis
- human health
- big data
- newly diagnosed
- prognostic factors
- papillary thyroid
- genome wide
- endoplasmic reticulum stress
- combination therapy
- mesenchymal stem cells
- squamous cell carcinoma
- genetic diversity
- current status
- bone marrow
- oxidative stress
- double blind
- lymph node metastasis
- childhood cancer
- disease virus