Immunophenotypic Heterogeneity of Polytypic Plasma Cells and the Impact on Myeloma Minimal Residual Disease Detection by Multiparameter Flow Cytometry.

Katie E SchouweilerNitin J KarandikarCarol J Holman

Published in: Cytometry. Part B, Clinical cytometry (2019)

Considerable immunophenotypic variation exists in PPC. The assessment of cytoplasmic light chain distribution, in conjunction with surface marker expression, is recommended to avoid diagnostic inaccuracy in MRD evaluation. © 2019 International Clinical Cytometry Society.

Keyphrases

flow cytometry
single cell
induced apoptosis
poor prognosis
cell cycle arrest
multiple myeloma
endoplasmic reticulum stress
newly diagnosed
binding protein
cell death
signaling pathway
label free