IFN-stimulated gene expression is independent of the IFNL4 genotype in chronic HIV-1 infection.
Katia MonteleoneGiuseppe Corano ScheriMaura StatzuCarla SelvaggiFrancesca FalascaNoemi GiustiniIvano MezzaromaOmbretta TurrizianiGabriella d'EttorreGuido AntonelliCarolina ScagnolariPublished in: Archives of virology (2016)
This study aimed to evaluate the association between the IFNL4 rs368234815 (ΔG/TT) dinucleotide polymorphism and the IFN response during chronic HIV-1 infection. We carried out genotyping analysis and measured the expression of IFN-stimulated genes (ISGs) (myxovirus resistance protein A [MxA], ISG15, ISG56, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like [APOBEC] 3F and APOBEC3G) on peripheral blood mononuclear cells collected from naïve and HAART-treated HIV-1-infected patients. There were no statistically significant differences in endogenous ISGs mRNA levels among HIV-1-positive patients bearing different IFNL4 genotypes, suggesting that ISG expression is independent of the IFNL4 genotype in HIV-1 infection.
Keyphrases
- antiretroviral therapy
- hiv infected patients
- hiv positive
- hiv infected
- human immunodeficiency virus
- binding protein
- gene expression
- poor prognosis
- dendritic cells
- end stage renal disease
- immune response
- newly diagnosed
- genome wide
- chronic kidney disease
- dna methylation
- ejection fraction
- crispr cas
- peritoneal dialysis
- high throughput
- prognostic factors
- south africa
- small molecule
- long non coding rna
- patient reported outcomes
- patient reported
- transcription factor