Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescence.

Ruiqi HanLi LiAlejandro Piñeiro UgaldeArieh TalZohar ManberEric Pinto BarberaVeronica Della ChiaraRan ElkonReuven Agami

Published in: Genome biology (2018)

Our study elucidates a novel cascade mediated by AP-1 and FOXF1 that regulates oncogene-induced senescence and further demonstrates the power of CRISPR-based functional genomic screens in deciphering the function of non-coding regulatory elements in the genome.

Keyphrases

genome wide
transcription factor
high glucose
endothelial cells
diabetic rats
crispr cas
dna methylation
genome editing
dna damage
high throughput
copy number
stress induced
drug induced
oxidative stress
binding protein
single cell